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Functional Genomics

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  • Functional Genomics

    As the Human Genome Project has determined the genetic sequence, the next step is to reveal each gene’s function and its control mechanism. Even though 99% of the gene sequence has been revealed, functions of the majority of the total genes are still unknown. That’s why researchers should focus on functional genomics.

    The figure below is an overview of the major areas of functional genomics which come into the scope of the project, illustrating their integration through bioinformatics and comparative genomics. There are three biological targets for functional genomic analysis - the mRNA (transcriptome), the genomic DNA (genomics), and the protein (proteomics). Bioinformatics enable us to integrate all kinds of biological data aiming to increase the understanding of biological process. Comparative genomics can help revealing the relationship of genome structure and function across different biological species or strains, finally for the identification of the mechanisms of genome evolution.

    Living in the era of functional genomics, we will essentially generate all types of biological information, and we will focus on gene products and their roles in the complex networks of biological processes under Antarctic environment in a high-throughput manner. This will have to be complemented by the development of new informatics tools, which enable predictions for important biological processes with complex data sets. Performing this project, we will be able to open a new chapter of Antarctic biology to understand adaptation and evolution for polar organisms.